How does Jefferson's use of punctuation and phrasing in this sentence help the reader see what he was trying to emphasize?"When in the Course of...

From a grammarian's point of view, there is something
significant in the fact that the sentence is one entire sentence and not broken into
different parts.  From a thematic point of view, it might be stressing how the need for
Colonial independence is something that has to be emphasized with the entire
relationship between the British and the Colonists.  Individual actions have to be seen
in this larger and more continuous scope, brought to light by the enormity of the first
sentence.  The fact that the clause that exists in between the commas is highly
significant.  It brings to light that nothing in the relationship between the Colonists
and the British can be put aside.  It all must be included in order to fully grasp the
need for independence and the call to action.  The clause in between the commas
discusses dissolution of "political bands" and argues that connection cannot exist in
such conditions.  This is an important point that cannot be discarded, and its inclusion
in the middle of the sentence brings